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Discovering, counting, cataloguing proteins

Imagine a complex technical system, like a car engine. Unbelievable to have hundreds of parts you don't know the function or exact place of. Within eukaryotic cells, however, still many hundreds of proteins have unknown functions and localisation. In a study that is part of Marcel Morgenstern's PhD thesis 82 new mitochondrial proteins were discovered by quantitative mass spectrometry and biochemical methods in the eukaryotic model organism baker's yeast. For an additional 119 proteins their mitochonrial localisation had been ambiguous. Mitochondria are small organelles within the cell that have about the size of a bacterium and are known as the cell's power plant. Furthermore, they fulfill numerous vital processes and are associated with many human diseases caused by cellular defects. The study was conducted together with a team of scientists from the universities of Freiburg, Homburg, and Rehovot (Israel) and was published in the current issue of Cell Reports.

Discovering, counting, cataloguing proteins

Schematic illustration of quantitative measurements of mitochondrial building blocks using mass spectrometry. Artwork: Christian D. Peikert

Read the Press Release University of Freiburg

Original publication:
Marcel Morgenstern, Sebastian B. Stiller, Philipp Lübbert, Christian D. Peikert, Stefan Dannenmaier, Friedel Drepper, Uri Weill, Philipp Höß, Reinhild Feuerstein, Michael Gebert, Maria Bohnert, Martin van der Laan, Maya Schuldiner, Conny Schütze, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann* and Bettina Warscheid* (2017).
(*corresponding author)

Definition of a High Confidence Mitochondrial Proteome at Quantitative Scale.

Cell Reports 19.

http://dx.doi.org/10.1016/j.celrep.2017.06.014

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