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PhD Position for the Study of ATPases in Cellular Stress Response

The Department of Biochemistry and Functional Proteomics at the University of Freiburg offers a

PhD Position for the Study of ATPases in Cellular Stress Response
The group is located in the Institute of Biology II and is part of the Cluster of Excellence BIOSS - Centre for Biological Signalling Studies. We are an interdisciplinary research team of biologists, biochemists, chemists, physicists, and bioinformaticians using state-of-the-art high resolution mass spectrometry combined with protein biochemistry and bioinformatics as key technology for functional proteomics studies on a cellular to system-wide level. The department provides excellent research conditions with modern cell and molecular biology laboratories and latest instrumentation (Orbitrap Elite, Q Exactive, nano-HPLC, fluorescence microscopy etc.). The project is funded by the Deutsche Forschungsgemeinschaft and performed in close cooperation with another PhD student working in the group of Prof. Jörg Koch at the University of Freiburg.

The project focuses on a universally conserved ATPase which is involved in the regulation of cellular stress response and found to be up-regulated in various human tumors. The major aims of the project are (i) to identify the molecular targets of the ATPase, (ii) to define their function in the modulation of cellular stress response and (iii) to reveal the underlying mechanisms.

The successful candidate will perform functional studies in the eukaryotic model organism Saccharomyces cerevisiae as well as in human cells. He/she will study the functional ATPase network including dynamic changes in the posttranslational state in response to oxidative stress and implications for modulating stress response in cells. This cutting-edge research project offers the unique possibility to employ a wide range of state-of-the-art technologies in biochemistry, mass spectrometry, proteomics and cell biology.

Applicants hold a diploma/master degree in biochemistry, biology or related disciplines. They should provide an excellent track record with a strong background in biochemistry, molecular biology and/or yeast genetics as well as great enthusiasm for membrane protein and signaling research. Excellent command of English and the ability to work in a team are required; experiences in protein chemistry, protein mass spectrometry or bioinformatics are highly advantageous. The University of Freiburg is an equal opportunity employer. Applications of women are encouraged.

The position is available as of February 1st, 2016. Interested candidates should send an application including CV, study certificates, areas of expertise and interests, list of publications, letter(s) of recommendation and references as a single PDF file until December 21st 2015 by email to Prof. Dr. Bettina Warscheid (bettina.warscheid@biologie.uni-freiburg.de).

For more information, see Hannemann et al., Antioxidants and Redox Signaling, 2015 and Wenk et al., Journal of Biological Chemistry 287, 2012.

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