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Prof. Dr. Bettina Warscheid

 

bwarscheid.jpg
Name Bettina Warscheid
Born August, 20th, 1971
Position Title Professor for Functional Proteomics and Biochemistry
Department of Biochemistry and Functional Proteomics,
Institute for Biology II and BIOSS Centre for
Biological Signaling Studies, University of Freiburg

  

Education

Academic education

1991 - 1997 Study of Chemistry, Technical University Dortmund, Diploma

Scientific graduation

1997 - 2002 PhD, Chemistry, Leibniz Institute of Analytical Sciences, Dortmund

 

Positions and Honours

Employment

Since 2010 Full Professor for Functional Proteomics and Biochemistry, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg
2009-2010 Professor for Clinical and Cellular Proteomics, Medical Faculty and Centre for Medical Biotechnology, University of Duisburg-Essen
2004-2009 Junior-Professor for Protein Mass Spectrometry, University of Bochum
2003-2010 Group Leader, Medical Proteome-Centre, University of Bochum
2002-2003 Postdoc, University of Maryland, College Park, MD, USA

 

Professional activities, awards and honours

Since 2017 Deputy Vice-President of the 'German Society of Proteome Research' (DGPF)
Since 2016 Dean of the Faculty of Biology, University of Freiburg
2014 - 2016 Academic Dean of Student Affairs, Faculty of Biology, University of Freiburg
Since 2010 Principal investigator of the 'Spemann Graduate School of Biology and Medicine' (SGBM) of the 'Exzellenzinitiative des Bundes und der Länder', University of Freiburg
Since 2010 Member and assessor at the board of directors, 'Zentrum für BioSystemAnalyse' (ZBSA)
Since 2010 Member of the executive board of the Excellence Cluster BIOSS
2010 Innovative research project award, Structural and Innovation Fond for Research (SI-BW), a program to support top engagements by the Ministry of Science, Research and the Arts Baden-Württemberg
2002-2003 DFG fellowship for research in the laboratories of Prof. Catherine Fenselau at the University of Maryland,
College Park, MD, and Prof. Robert Cotter at the Johns Hopkins University, School of
Medicine, Baltimore, MD, USA
1996 Undergraduate studies fellowship from the German Academic Exchange Program for research stay at Leiden University, NL

 

Selected Publications (2007-2017)

  • Charting organellar importomes by quantitative mass spectrometry.
    Peikert CD, Mani J, Morgenstern M, Sandro K, Knapp B, Wenger C, Harsman A, Oeljeklaus S, Schneider A*, Warscheid B*.
    Nat Commun. 2017;
    *corresponding author
  • Myofibrillar Z-discs are a protein phosphorylation hot spot with protein kinase C (PKC alpha) modulating protein dynamics.
    Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke A, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PFM, Radziwill G, Fürst DO, Warscheid, B.
    Mol Cell Proteomics. 2016;
  • The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.
    Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B*, Schneider A*.
    Nat Commun. 2016; 7:13707.
    *corresponding author
  • Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein.
    Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S.
    Cell. 2016;167(2):471-83.
  • Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria.
    Käser S, Oeljeklaus S, Týc J, Vaughan S, Warscheid B*, Schneider A*.
    Proc Natl Acad Sci U S A. 2016;113(31):E4467-75.
    *corresponding author
  • Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins.
    Stiller SB, Höpker J, Oeljeklaus S, Schütze C, Schrempp SG, Vent-Schmidt J, Horvath SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N, Wiedemann N.
    Cell Metab. 2016;23(5):901-8.
  • Regulation of peroxisome dynamics by phosphorylation.
    Oeljeklaus S, Schummer A, Mastalski T, Platta WH, Warscheid B
    Biochim Biophys Acta. 2016; 1863:1027-37.
  • Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B*, Chacinska A.* (2015)
    Nature. 524(7566):485-8.
    *corresponding author
  • Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.
    Schwarz JJ, Wiese H, Tölle RC, Zarei M, Dengjel J, Warscheid B*, Thedieck K* (2015)
    Mol Cell Proteomics. 14(8):2042-55
    *corresponding author
  • Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.
    Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt H, Radziwill G, Warscheid B (2014)
    Biochim Biophys Acta, pii: S1570-9639(14)00225-8.
  • Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances.
    Mani J, Desy S, Niemann M, Chanfon A, Oeljeklaus S, Pusnik A, Schmidt O, Gerbeth C, Meisinger C, Warscheid B, Schneider A.
    Nat Commun. 2015; 6:6646.
  • The membrane proteome of sensory cilia to the depth of olfactory receptors.
    Kuhlmann K, Tschapek A, Wiese H, Eisenacher M, Meyer HE, Hatt H, Oeljeklaus S, Warscheid B (2014)
    Mol Cell Proteomics, 13:1828-43.
  • SILAC labeling of yeast for the study of membrane protein complexes.
    Oeljeklaus S, Schummer A, Suppanz I, Warscheid B.
    Methods Mol Biol. 2014; 1188:23-46.
  • Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization.
    Wiese H, Kuhlmann K, Wiese S, Stoepel NS, Pawlas M, Meyer HE, Stephan C, Eisenacher M, Drepper F, Warscheid B (2014)
    J Proteome Res. 13(2):1128-1137.
  • A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for ER reticulon homology proteins in peroxisome biogenesis.
    David C, Koch JP, Oeljeklaus S, Laernsack A, Melchior S, Wiese S, Schummer A, Erdmann R, Warscheid B*, Brocard C* (2013) *corresponding authors
    Mol Cell Proteomics, 2013 May 20.
  • Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.
    Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T.
    Cell. 2013; 154(3):596-608.
  • Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology.
    Niemann M, Wiese S, Mani J, Chanfon A, Jackson C, Meisinger C, Warscheid B*, Schneider A* (2013). *corresponding authors
    Mol Cell Proteomics: M112.023093
  • MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.
    Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheau-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012).
    Cell 151(7):1528-1541.
  • Identification of Core Components and Transient Interactors of the Peroxisomal Importomer by Dual-track SILAC Analysis.
    Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B (2012).
    J Proteome Res 11(4):2567-2580.
  • Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and micro-array analysis.
    Kaller M, Liffers ST, Oeljeklaus S, Kuhlmann K, Röh S, Hoffmann R, Warscheid B, Hermeking H.
    Mol Cell Proteomics. 2011; 10(8):M111.010462.
  • New dimensions in the study of protein complexes using quantitative mass spectrometry.
    Oeljeklaus S, Meyer HE, Warscheid B.
    FEBS Lett. 2009; 583(11):1674-83.
  • Novel insight into stimulus-induced plasticity of the olfactory epithelium in Mus musculus by quantitative proteomics.
    Barbour J, Neuhaus EM, Piechura H Stoepel N, Brunert EMD, Mashukova A, Sitek B, Stühler K, Meyer HE, Hatt H, Warscheid B.
    J Proteome Res. 2008; 7(4):1594-1605.
  • Study of early leaf senescence in Arabidopsis thaliana by quantitative proteomics using reciprocal 14N/15N-labeling and difference gel electrophoresis.
    Hebeler R, Oeljeklaus S Reidegeld KA, Eisenacher M, Stephan C, Sitek B, Stühler K, Meyer HE, Sturre MJG, Dijkwel PP, Warscheid B.
    Mol Cell Proteomics. 2008; 7(1):108-120.
  • Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
    Mick DU, Wagner K, van der Laan M, Perschil I, Pawlas M, Meyer HE, Warscheid B, Rehling P.
    EMBO J. 2007; 26(20):4347-58.
  • Characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
    Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham, HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJA, Warscheid B (2007).
    Mol Cell Proteomics 6(12):2045-57.
  • Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research.
    Wiese S, Reidegeld KA, Meyer HE, Warscheid B.
    Proteomics. 2007; 7(3):340-50.

 

See here for the full list of my publications

 

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