News
Site News
Two Positions for Postdoctoral Scientists in Proteomics
Two exciting postdoc opportunities within a well-established and highly productive collaboration network.
How to deal with missing values in proteomics data
Missing values prevent the feasibility of methods for analysis, can cause bias, and may negatively impact statistical power. We developed the concept of data-driven selection of an imputation algorithm (DIMA) which optimally selects an imputation method for a given proteomics data set.
Structural model of the peroxisomal docking complex
Our paper on the peroxisomal receptor docking complex is online! In collaboration with the Gatsogiannis lab at MPI Dortmund and the Erdmann lab from Ruhr University in Bochum using an integrative approach we were able to derive the first structural model of the challenging peroxisomal docking complex Pex14/Pex17.
Marcel Morgenstern defends PhD thesis
Marcel Morgenstern successfully defended his PhD thesis, featuring groundbreaking quantitative proteomics studies on mitochondrial proteomes.
Lena leaves and mass specs on
We are all sad to say goodbye to Lena and wish her all the best at Celonic in Basel.
Sven Fischer defended PhD thesis
We are happy to report a new Dr in the group. Sven Fischer successfully defended his PhD thesis in February this year.
Regulation of the transport of citrate synthase into peroxisomes
In close collaboration with the Schuldiner lab from the Weizmann Institute, Israel, and the Erdmann lab from the Ruhr University Bochum, Germany, Renate Maier and Andreas Schummer revealed that phosphorylation of Pex14, a core component of the peroxisomal import machinery, provides a posttranslational mechanism to redistribute peroxisomal citrate synthase Cit2 to the cytosol. This helps yeast cells to rapidly adjust their metabolism to the available carbon source.
Structural model of the peroxisomal docking complex
Our preprint on the peroxisomal receptor docking complex is online! In collaboration with the Gatsogiannis lab at MPI Dortmund and the Erdmann lab from Ruhr University in Bochum using an integrative approach we were able to derive the first structural model of the challenging peroxisomal docking complex Pex14/Pex17.
Two Early Stage Researchers started PhD within PERICO ITN
Alexandros Zografakis and Hirakjyoti Das have recently joined our group. They started their PhD within the Innovative Training Network “PERoxisome Interactions and COmmunication” (PERICO) funded by the European Union's Horizon 2020 programme.
Featured article at Nature Communications
The article 'Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species' by Ida Suppanz and coworkers has been featured in a collection on biomolecular mass spectrometry.
Christian Peikert defends PhD thesis
Bioinformatician Christian Peikert successfully defended his PhD thesis "Bioinformatics applications for analysis and visualization of mass spectrometry based proteomics data".
Jennifer Schwarz defends PhD thesis
Jennifer Schwarz successfully defended her PhD thesis 'Study of the mTOR kinase and PTP1B phosphatase substrate networks by functional proteomic approaches'.
Start of EU-funded MARIE SKŁODOWSKA-CURIE INNOVATIVE TRAINING NETWORK PerICo 2018-2022
Future European Science Leaders to Work on Cutting-edge Peroxisome Research “Peroxisome Interactions and Communication”
EuPA Poster price for Stefan Dannenmaier
At this year's summer school of the European Proteomics Association (EuPA) Stefan Dannenmaier was awarded a Best-Poster price for his contribution entitled "2nSILAC - An advanced native SILAC strategy for mitochondrial proteomics in Saccharomyces cerevisiae".
Nano-switches in the cell
In a joint study conducted by Ida Suppanz and coworkers in Bettina Warscheid's lab with the group of Agnieszka Chacinska from the Centre of New Technologies in Warsaw a new mechanism was discovered that enables mitochondria with impaired redox balance to regulate the synthesis of new proteins in the cytoplasm. The results were published in the current issue of "Nature Communications".
Discovering, counting, cataloguing proteins
Imagine a complex technical system, like a car engine. Unbelievable to have hundreds of parts you don't know the function or exact place of. Within eukaryotic cells, however, still many hundreds of proteins have unknown functions and localisation. In a study that is part of Marcel Morgenstern's PhD thesis 82 new mitochondrial proteins were discovered by quantitative mass spectrometry and biochemical methods in the eukaryotic model organism baker's yeast. For an additional 119 proteins their mitochonrial localisation had been ambiguous. Mitochondria are small organelles within the cell that have about the size of a bacterium and are known as the cell's power plant. Furthermore, they fulfill numerous vital processes and are associated with many human diseases caused by cellular defects. The study was conducted together with a team of scientists from the universities of Freiburg, Homburg, and Rehovot (Israel) and was published in the current issue of Cell Reports.
Charting organellar importomes by quantitative mass spectrometry
In a new study of the human parasite Trypanosoma brucei we define the entirety of the mitochondrial proteins imported from the cytosol. This work is part of Christian Peikert's PhD thesis and was now published in Nature Communications. The project is conducted together with the group of André Schneider from the University of Bern.
Successfully defended dissertation
Andreas Schummer has just defended his dissertation entitled 'Regulation of peroxisome biogenesis and matrix protein import in Saccharomyces cerevisiae'.
Z-disc protein phosphorylation hot spot
Lena's large scale Z-Disc phosphorylation study revealing all you wanted to know about the role of Filamin C in Z-Discs was now published in MCP.
How Complex Cells Developed
A Joint paper with the group of André Schneider from the University of Bern on the protein import into mitochondria of trypanosomes was published in Nature Communications. Trypanosomes are single-cell human parasites that cause sleeping sickness.