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Regulation of the transport of citrate synthase into peroxisomes

In close collaboration with the Schuldiner lab from the Weizmann Institute, Israel, and the Erdmann lab from the Ruhr University Bochum, Germany, Renate Maier and Andreas Schummer revealed that phosphorylation of Pex14, a core component of the peroxisomal import machinery, provides a posttranslational mechanism to redistribute peroxisomal citrate synthase Cit2 to the cytosol. This helps yeast cells to rapidly adjust their metabolism to the available carbon source.

Regulation of the transport of citrate synthase into peroxisomes

Phosphorylation (P) of the peroxisomal import machinery redistributes peroxisomal citrate synthase Cit2 to the cytosol. Image: Daniel Wendscheck

The results were published in the current issue of the open-access journal "Fronties in Cell and Developmental Biology". Checkout the original research article at:

dx.doi.org/10.3389/fcell.2020.549451

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