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Structural model of the peroxisomal docking complex

Our preprint on the peroxisomal receptor docking complex is online! In collaboration with the Gatsogiannis lab at MPI Dortmund and the Erdmann lab from Ruhr University in Bochum using an integrative approach we were able to derive the first structural model of the challenging peroxisomal docking complex Pex14/Pex17.

Structural model of the peroxisomal docking complex

Model of the docking complex and cargo import. Image: Daniel Wendscheck

Daniel Wendscheck and coworkers used native mass spectrometry (MS) and crosslinking MS to analyse the composition, topology and sites of interaction of this highly dynamic protein machinery. It was fascinating to see how these parts of the puzzle came together with the biochemical characterisation by Tobias Hansen in the Bochum group and the cryo-electron microscopy work done by Pascal Lill at MPI in Dortmund.

 

Check out the preprint on BioRxiv:

https://www.biorxiv.org/content/10.1101/854497v2

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