You are here: Home Team Prof. Dr. Bettina Warscheid
Document Actions

Prof. Dr. Bettina Warscheid


Name Bettina Warscheid
Born 20.08.1971
Institution Institute of Biology II, University of Freiburg, Schänzlestr. 1, 79104 Freiburg
Contact Phone: +49-761-203-2690,
Email: bettina.warscheid@biologie.uni-freiburg.de
Position Full Professor (W3) for Biochemistry and Functional Proteomics
ORCID ORCID logo https://orcid.org/0000-0001-5096-1975
  CIBSS principal investigator profile page


Academic Education

1991 – 1997 Study of Chemistry, TU Dortmund and Leiden University (NL), Diploma
1997 – 2002 PhD, Analytical Chemistry, Leibniz-Institute of Analytical Sciences, TU Dortmund



Since 2010 Full Professor (W3) for Biochemistry and Functional Proteomics, Faculty of Biology, University of Freiburg
2009 – 2010 Professor (W2) for Clinical and Cellular Proteomics, Medical Faculty and Centre for Medical Biotechnology, University of Duisburg-Essen
2004 – 2009 Junior-Professor (W1) for Protein Mass Spectrometry, Molecular Medicine, Medical Faculty, University of Bochum
2003 – 2010 Group leader, Medical Proteome-Centre, University of Bochum
2002 – 2003 Postdoctoral Research Fellow, University of Maryland, College Park and Johns Hopkins University, School of Medicine, Baltimore, MD, USA


Academic activities, awards and honors

Since 2019 Principle Investigator and Steering Board Member of the Excellence Cluster CIBSS Centre for Integrative Biological Signalling Studies,
Coordinator of area CIBSS-D ‘Integrative Signalling Technologies’
Since 2019 Principle Investigator of the SFB 1381 ‘Dynamic organization of cellular protein machineries: from biogenesis and modular assembly to function’.
May 2018 Member of the CIBSS speaker team presenting the CIBSS program ‘Signalling across scales: from mechanistic understanding to control-of-function’ to the DFG reviewer panel
2018 – 2019 Vice Dean of the Faculty of Biology, University of Freiburg
Since 2017 Deputy Vice-President of the 'German Society of Proteome Research' (DGPF)
2016 – 2018 Dean of the Faculty of Biology, University of Freiburg
2016 – 2018 Member of the Senate, University of Freiburg
2014 – 2016 Dean of Student Affairs, Faculty of Biology, University of Freiburg
Since 2013 Principal investigator of TRR 130 'B Cells: Immunity and Autoimmunity'
Since 2011 Principal investigator of the 'Spemann Graduate School of Biology and Medicine' (SGBM) of the 'Exzellenzinitiative des Bundes und der Länder', University of Freiburg
Dec 2011 Member of the BIOSS speaker team presenting the BIOSS-2 program ‘Signaling research from analysis to synthesis’ to the DFG reviewer panel
2010 – 2020 Steering Board Member of the Excellence Cluster BIOSS Centre for Biological Signalling Studies
Since 2010 Principle Investigator of the Excellence Cluster BIOSS
2010 Innovative research project award, Structural and Innovation Fond for Research (SI-BW), a program to support top engagements by the Ministry of Science, Research and the Arts Baden-Württemberg
2002 – 2003 DFG fellowship for research in the laboratories of Prof. Catherine Fenselau at the University of Maryland,
College Park, MD, and Prof. Robert Cotter at the Johns Hopkins University, School of
Medicine, Baltimore, MD, USA
1996 Undergraduate studies fellowship from the German Academic Exchange Program for research stay at Leiden University, NL


bioRxiv preprints

  • Pex14p phosphorylation modulates import of citrate synthase 2 into peroxisomes in Saccharomyces cerevisiae
    Schummer A*, Maier R*, Gabay-Maskit S, Hansen T, Mühlhäuser WWD, Suppanz I, Fadel A, Schuldiner M, Girzalsky W, Oeljeklaus S, Zalckvar E, Erdmann R, Warscheid B.
    bioRxiv preprint first; https://doi.org/10.1101/2020.07.03.186833
    *shared first authorship
  • Towards the molecular architecture of the peroxisomal receptor docking complex
    Lill P*, Hansen T*, Wendscheck D*, Klink BU, Jeziorek, T, Miehling, J, Bender J, Drepper F, Girzalsky W, Warscheid B°, Erdmann R°, Gatsogiannis C.
    bioRxiv preprint first; https://doi.org/10.1101/854497
    *shared first authorship; °equal contribution


Selected Publications (2007-2020)

  • Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C.
    Reimann L*, Schwäble AN*, Fricke A, Muehlhaeuser W, Leber Y, Lohanadan K, Puchinger M, Schäuble S, Fässler E Wiese, H, Reichenbach C, Knapp B, Peikert CD, Drepper F, Hahn U, Kreutz C, van der Ven PFM, Radziwill G, Djinović-Carugo K, Fürst DO, Warscheid B (2020).
    Commun Biol, 3:253.
  • Defining the substrate spectrum of the TIM22 complex identifies pyruvate carrier subunits as unconventional cargos
    Gomkale R, Cruz-Zaragoza LD, Suppanz I, Guiard B, Montoya J, Pacheu-Grau D, Warscheid B, Rehling P (2020).
    Curr Biol, 30(6):1119-1127.
  • Ubx2 monitors the mitochondrial protein entry gate.
    Mårtensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T (2019).
    Nature, 569:679-683. Feature Article in News & Views; Nature, 569:635-637.
  • Mitochondrial proteins: from biogenesis to functional networks.
    Pfanner N, Warscheid B, Wiedemann N (2019).
    Nat Rev Mol Cell Bio, 20:267-284.
  • Quantitative proteomics identifies zinc-based redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
    Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B (2018).
    Nat Commun, 9:324.
  • Complete native stable isotope labeling by amino acids of Saccharomyces cerevisiae for global proteomic analysis.
    Dannenmaier S, Stiller S, Morgenstern M, Lübbert P, Oeljeklaus S, Wiedemann N, Warscheid B (2018).
    Anal Chem, 90:10501-10509.
  • Definition of a high confidence mitochondrial proteome at quantitative scale.
    Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmeier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B (2017).
    Cell Rep, 9:2836-2852.
  • Charting organellar importomes by quantitative mass spectrometry.
    Peikert CD, Mani J, Morgenstern M, Sandro K, Knapp B, Wenger C, Harsman A, Oeljeklaus S, Schneider A*, Warscheid B* (2017).
    Nat Commun, 8:15272-15272.
    *corresponding author
  • Myofibrillar Z-discs are a protein phosphorylation hot spot with protein kinase C (PKCα) modulating protein dynamics.
    Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke A, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PFM, Radziwill G, Fürst DO, Warscheid, B.
    Mol Cell Proteomics. 2016;
  • Regulation of peroxisome dynamics by phosphorylation.
    Oeljeklaus S, Schummer A, Mastalski T, Platta WH, Warscheid B (2016).
    Biochim Biophys Acta Mol Cell Res, 1863:1027-1037.
  • Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery.
    Chan A, Schummer A, Fischer S, Bender J, Drepper F, Oeljeklaus S, Kunau WH, Girzalsky W, Warscheid B*, Erdmann R* (2016).
    Eur J Cell Biol, 95(12):585-597.
  • The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.
    Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B*, Schneider A*.
    Nat Commun. 2016; 7:13707.
    *corresponding author
  • Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein.
    Richter-Dennerlein R, Oeljeklaus S, Lorenzi I, Ronsör C, Bareth B, Schendzielorz AB, Wang C, Warscheid B, Rehling P, Dennerlein S.
    Cell. 2016;167(2):471-83.
  • Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener ME, Oeljeklaus S, Varabyova A, Lirski M, Chroscicki P, Mroczek S, Januszewicz E, Dziembowski A, Koblowska M, Warscheid B*, Chacinska A.* (2015)
    Nature. 524(7566):485-8.
    *corresponding author
  • Structural insights into cargo recognition by the yeast PTS1-receptor.
    Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta H, Zimmermann B, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R (2015).
    J Biol Chem, 290:26610-26626.
  • Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate.
    Schwarz JJ, Wiese H, Tölle RC, Zarei M, Dengjel J, Warscheid B*, Thedieck K* (2015)
    Mol Cell Proteomics. 14(8):2042-55
    *corresponding author
  • Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.
    Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt H, Radziwill G, Warscheid B (2014)
    Biochim Biophys Acta, pii: S1570-9639(14)00225-8.
  • Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization.
    Wiese H, Kuhlmann K, Wiese S, Stoepel NS, Pawlas M, Meyer HE, Stephan C, Eisenacher M, Drepper F, Warscheid B (2014)
    J Proteome Res. 13(2):1128-1137.
  • The membrane proteome of sensory cilia to the depth of olfactory receptors.
    Kuhlmann K, Tschapek A, Wiese H, Eisenacher M, Meyer HE, Hatt H, Oeljeklaus S, Warscheid B (2014)
    Mol Cell Proteomics, 13:1828-43.
  • A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for ER reticulon homology proteins in peroxisome biogenesis.
    David C, Koch JP, Oeljeklaus S, Laernsack A, Melchior S, Wiese S, Schummer A, Erdmann R, Warscheid B*, Brocard C* (2013) *corresponding authors
    Mol Cell Proteomics, 2013 May 20.
  • Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology.
    Niemann M, Wiese S, Mani J, Chanfon A, Jackson C, Meisinger C, Warscheid B*, Schneider A* (2013). *corresponding authors
    Mol Cell Proteomics: M112.023093
  • Identification of Core Components and Transient Interactors of the Peroxisomal Importomer by Dual-track SILAC Analysis.
    Oeljeklaus S, Reinartz BS, Wolf J, Wiese S, Tonillo J, Podwojski K, Kuhlmann K, Stephan C, Meyer HE, Schliebs W, Brocard C, Erdmann R, Warscheid B (2012).
    J Proteome Res 11(4):2567-2580.
  • MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.
    Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheau-Grau D, Lorenzi I, Sasarman F, Weraarpachai W, Shoubridge EA, Warscheid B, Rehling P (2012).
    Cell 151(7):1528-1541.
  • New dimensions in the study of protein complexes using quantitative mass spectrometry.
    Oeljeklaus S, Meyer HE, Warscheid B.
    FEBS Lett. 2009; 583(11):1674-83.
  • Characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling.
    Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, Almeida JA, Eisenacher M, Stephan C, Hayen H, Schollenberger L, Korosec T, Waterham, HR, Schliebs W, Erdmann R, Berger J, Meyer HE, Just W, Azevedo JE, Wanders RJA, Warscheid B (2007).
    Mol Cell Proteomics 6(12):2045-57.
  • Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome research.
    Wiese S, Reidegeld KA, Meyer HE, Warscheid B.
    Proteomics. 2007; 7(3):340-50.


See here for the full list of my publications


Personal tools